NOTE: You can also install Wine on Mac OS Catalina 10.15 by following the steps in this article. In this article, we will configure Wine to run a Windows-compatible program on Apple PC, Apple’s new operating system. How to Install PlayOnMac on macOS High Sierra.In our previous articles, we installed PlayOnMac, which provides a GUI to the Wine infrastructure. There are other programs that allow you to run Windows applications on macOS. You can use Wine to run Windows programs on your Mac because this is both free and specific. Wine (Wine is not an emulator) is an excellent program that allows you to run Windows programs and games on Linux and macOS. In this article, we will build Wine on Mac OS.